High-throughput Production of Diverse Xenobiotic Metabolites with P450-transduced Huh7 Hepatoma Cell Lines
C.-m. Lee, K. H. Liu, G. Singer, G. W. Miller, S. Li, D. P. Jones, E. T. Morgan
This paper develops P450-expressing Huh7 cell lines to generate xenobiotic metabolites, enabling high-throughput analysis of drug metabolism and identification of specific enzyme-substrate interactions.
bioRxiv · Mar 12, 2022 · PreprintPharmacology & Toxicology