Author

G. W. Miller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 4 Bioengineering· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 4 Organism:human· 4 Assay:metabolomics· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

R. J. Price· 3 shared C. M. Gorick· 2 shared D. P. Jones· 2 shared M. L. Bucher· 2 shared N. D. Sheybani· 2 shared A. C. Debski· 1 shared A. David· 1 shared A. Gerard· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersBioengineering

R. J. Price

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Focused Ultrasound Blood-Brain Barrier Opening Arrests the Growth and Formation of Cerebral Cavernous Malformations

D. G. Fisher, K. A. Sharifi, I. M. Shah, C. M. Gorick, V. R. Breza, A. C. Debski, M. Hoch, T. Cruz, J. D. Samuels, J. Sheehan, D. Schlesinger, D. Moore, J. R. Lukens, P. Tvrdik, G. W. Miller, R. J. Price

This paper shows that focused ultrasound blood-brain barrier opening can stop and prevent the growth of cerebral cavernous malformations in mice.

bioRxiv · Jan 31, 2024 · PreprintBioengineering

Tricyclic and tetracyclic antidepressants upregulate VMAT2 activity and rescue disease-causing VMAT2 variants

X. Wang, I. Marmouzi, P. S. Finnie, S. I. Stove, M. L. Bucher, T. V. Lipina, A. J. Ramsey, G. W. Miller, A. Salahpour

bioRxiv · Oct 9, 2023Pharmacology & Toxicology

Paracetamol/acetaminophen hepatotoxicity: new markers for monitoring the elimination of the reactive N-Acetyl-p-benzoquinone imine

E. Gorrochategui, M. Le Vee, H. Selmi, A. Gerard, J. Chaker, A. M. Krais, C. Lindh, O. Fardel, C. Chevrier, P. Le Cann, G. W. Miller, R. Barouki, B. Jegou, T. Gicquel, D. Kristensen, A. David

The paper identifies thiomethyl metabolites as new markers to monitor NAPQI elimination after therapeutic use or intoxication.

bioRxiv · Apr 28, 2023 · PreprintPharmacology & Toxicology

High-throughput Production of Diverse Xenobiotic Metabolites with P450-transduced Huh7 Hepatoma Cell Lines

C.-m. Lee, K. H. Liu, G. Singer, G. W. Miller, S. Li, D. P. Jones, E. T. Morgan

This paper develops P450-expressing Huh7 cell lines to generate xenobiotic metabolites, enabling high-throughput analysis of drug metabolism and identification of specific enzyme-substrate interactions.

bioRxiv · Mar 12, 2022 · PreprintPharmacology & Toxicology

Cross-species metabolomic analysis of DDT and Alzheimer's disease-associated tau toxicity

V. Kalia, M. M. Niedzwiecki, J. M. Bradner, F. K. Lau, M. L. Bucher, K. E. Manz, Z. Coates Fuentes, K. D. Pennell, M. Picard, D. I. Walker, W. T. Hu, D. P. Jones, G. W. Miller

This study investigates the link between DDT exposure and tau toxicity in C. elegans and humans, finding that DDT exacerbates mitochondrial dysfunction caused by tau aggregation.

bioRxiv · Jun 14, 2021 · PreprintPharmacology & Toxicology

ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma

N. D. Sheybani, S. Paul, K. S. McCauley, V. Breza, S. S. Berr, G. W. Miller, K. D. Neumann, R. J. Price

This study shows that timing mCD47 antibody injection relative to focused ultrasound (FUS) BBB disruption affects antibody delivery to gliomas, with post-FUS injection improving delivery and reducing tumor growth.

bioRxiv · Jul 27, 2020Bioengineering

Transcriptomic Response of Brain Tissue to Focused Ultrasound-Mediated Blood-Brain Barrier Disruption Depends Strongly on Anesthesia

A. S. Mathew, C. M. Gorick, E. A. Thim, W. J. Garrison, A. L. Klibanov, G. W. Miller, N. D. Sheybani, R. J. Price

This study examines how different anesthetics affect the transcriptomic response of brain tissue to focused ultrasound-mediated blood-brain barrier disruption in mice.

bioRxiv · Jul 24, 2020Bioengineering