An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput screens
R. W. Coukos, D. Yao, M. L. Sanchez, E. T. Strand, J. S. Weissman, M. C. Bassik, A. Y. Ting
The paper develops HiLITR, a tool to study protein trafficking by linking localization to reporter gene expression, and identifies genes affecting mitochondrial and ER membrane protein trafficking.
bioRxiv · Apr 11, 2021Bioengineering