A bottom-up approach for the de novo design of functional proteins
C. Yang, F. Sesterhenn, J. Bonet, E. v. Aalen, L. Scheller, L. Abriata, J. Cramer, X. Wen, S. Rosset, S. Georgeon, T. S. Jardetzky, T. Krey, M. Fussenegger, M. Merkx, B. Correia
This paper introduces a bottom-up method for designing functional proteins tailored to complex motifs, demonstrating their use as biosensors and signaling ligands.
bioRxiv · Mar 11, 2020 · PreprintBioengineering