Author

M. Merkx

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Assay:metagenomics· 1 Organism:non-human primate· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

E. A. van Aalen· 2 shared E. T. L. Hanckmann· 2 shared A. Grawe· 1 shared A. J. M. Loonen· 1 shared A.-M. Makri Pistikou· 1 shared B. Correia· 1 shared B. J. H. M. Rosier· 1 shared B. Timmermans· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBioengineering

E. A. van Aalen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Bioluminescent detection of viral surface proteins using branched multivalent protein switches

A. Grawe, C. M. Spruit, R. P. de Vries, M. Merkx

This paper introduces a modular bioluminescent sensor platform (dark-LUX) for detecting viral surface proteins using multivalent binding domains and NanoBiT technology, demonstrating its application with influenza A virus proteins.

bioRxiv · Sep 22, 2023Biochemistry

Critical thermal maxima and oxygen uptake in Elysia viridis (Montagu, 1804), a sea slug capable of photosynthesis

E. M. J. Laetz, C. Kahyaoglu, N. M. Borgstein, M. Merkx, S. van der Meij, W. Verberk

This study examines how oxygen dynamics affect thermal tolerance in the photosynthetic sea slug Elysia viridis under different feeding and temperature conditions.

bioRxiv · Jun 19, 2023 · PreprintPhysiology

Fast bioluminescent nucleic acid detection using one-pot isothermal amplification and dCas9-based split luciferase complementation

H. J. van der Veer, E. A. van Aalen, C. M. S. Michielsen, E. T. L. Hanckmann, J. Deckers, M. M. G. J. van Borren, J. Flipse, A. J. M. Loonen, J. P. H. Schoeber, M. Merkx

The paper develops a bioluminescent nucleic acid detection platform (LUNAS) integrated with RPA for rapid, sensitive, and portable diagnostics of SARS-CoV-2 RNA.

bioRxiv · Sep 12, 2022Bioengineering

RAPPID: a platform of ratiometric bioluminescent sensors for homogeneous immunoassays

Y. Ni, B. J. H. M. Rosier, E. A. van Aalen, E. T. L. Hanckmann, L. Biewenga, A.-M. Makri Pistikou, B. Timmermans, C. Vu, S. Roos, R. Arts, W. Li, T. F. A. de Greef, F. J. M. van Kuppeveld, B.-J. Bosch, M. Merkx

RAPPID is a homogeneous immunoassay platform using ratiometric bioluminescent sensors for direct in-sample calibration and quantitative detection of biomarkers.

bioRxiv · Oct 31, 2020 · PreprintBioengineering

A bottom-up approach for the de novo design of functional proteins

C. Yang, F. Sesterhenn, J. Bonet, E. v. Aalen, L. Scheller, L. Abriata, J. Cramer, X. Wen, S. Rosset, S. Georgeon, T. S. Jardetzky, T. Krey, M. Fussenegger, M. Merkx, B. Correia

This paper introduces a bottom-up method for designing functional proteins tailored to complex motifs, demonstrating their use as biosensors and signaling ligands.

bioRxiv · Mar 11, 2020 · PreprintBioengineering