Penicillin Binding Protein Substitutions Co-occur with Fluoroquinolone Resistance in 'Epidemic Lineages of Multi Drug-Resistant Clostridioides difficile
K. E. Dingle, J. Freeman, X. Didelot, D. W. Eyre, J. Swann, W. Spittal, E. V. Clark, K. A. Jolley, A. S. Walker, M. H. Wilcox, D. W. Crook
The paper identifies amino acid substitutions in penicillin binding proteins (PBPs) PBP1 and PBP3 as a mechanism of cephalosporin resistance in C. difficile, which co-occurs with fluoroquinolone resistance in epidemic lineages.
bioRxiv · May 23, 2022 · PreprintMicrobiology