M. H. Wilcox

Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile

This study identifies a mutation in C. difficile that causes metronidazole resistance and links it to fluoroquinolone resistance, contributing to the spread of drug-resistant strains.

Penicillin Binding Protein Substitutions Co-occur with Fluoroquinolone Resistance in 'Epidemic Lineages of Multi Drug-Resistant Clostridioides difficile

The paper identifies amino acid substitutions in penicillin binding proteins (PBPs) PBP1 and PBP3 as a mechanism of cephalosporin resistance in C. difficile, which co-occurs with fluoroquinolone resistance in epidemic lineages.

Pilot study: Trehalose-induced remodelling of the human microbiota affects Clostridioides difficile infection outcome in an in vitro colonic model

This study shows that trehalose supplementation remodels the human gut microbiota, preventing simulated Clostridioides difficile infection in an in vitro model.

Profiling the effects of rifaximin on the healthy human colonic microbiota using a chemostat model

This study evaluates three rifaximin formulations on the human colonic microbiota using chemostat models, finding that formulation {kappa} caused the least disruption.

Hash-based core genome multi-locus sequencing typing for Clostridium difficile

This paper introduces hash-cgMLST, a method for rapid genome comparison in Clostridium difficile, showing it matches standard cgMLST performance but with faster processing.

The predictive value of quantitative nucleic acid amplification detection of Clostridium difficile toxin gene for faecal sample toxin status and patient outcome

This study evaluates the predictive value of quantitative nucleic acid amplification test (NAAT) cycle threshold (CT) values for C. difficile toxin gene in faecal samples to assess toxin status and patient outcomes.

Simulation of enteric colonisation by and screening for Carbapenemase Producing Enterobacteriaceae using an in-vitro human gut model.

The paper simulates enteric colonization by Carbapenemase Producing Enterobacteriaceae (CPE) using an in-vitro human gut model and screens for CPE.

A role for tetracycline selection in the evolution of Clostridium difficile PCR-ribotype 078

The paper investigates the evolutionary history of Clostridium difficile RT078, finding that tetracycline resistance genes, particularly tetM, were acquired independently in multiple clonal expansions, contributing to its increased prevalence.