Author

W. Spittal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:C. elegans· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metagenomics· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

M. H. Wilcox· 2 shared A. Buckley· 1 shared A. S. Walker· 1 shared D. W. Crook· 1 shared D. W. Eyre· 1 shared D. Wang· 1 shared E. Clark· 1 shared E. V. Clark· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

M. H. Wilcox

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Penicillin Binding Protein Substitutions Co-occur with Fluoroquinolone Resistance in 'Epidemic Lineages of Multi Drug-Resistant Clostridioides difficile

K. E. Dingle, J. Freeman, X. Didelot, D. W. Eyre, J. Swann, W. Spittal, E. V. Clark, K. A. Jolley, A. S. Walker, M. H. Wilcox, D. W. Crook

The paper identifies amino acid substitutions in penicillin binding proteins (PBPs) PBP1 and PBP3 as a mechanism of cephalosporin resistance in C. difficile, which co-occurs with fluoroquinolone resistance in epidemic lineages.

bioRxiv · May 23, 2022 · PreprintMicrobiology

Pilot study: Trehalose-induced remodelling of the human microbiota affects Clostridioides difficile infection outcome in an in vitro colonic model

A. Buckley, I. Moura, N. Arai, W. Spittal, E. Clark, Y. Nishida, H. Harris, K. Bentley, G. DAVIS, D. Wang, S. Mitra, T. Higashiyama, M. H. Wilcox

This study shows that trehalose supplementation remodels the human gut microbiota, preventing simulated Clostridioides difficile infection in an in vitro model.

bioRxiv · Feb 16, 2021Microbiology