Thymically imprinted differential responsivity of naive CD4 T cells to IL2 results in a heterogeneity of both Treg induction and subsequent effector functioning
N. D. Pennock, Y. Qian, K. Ishihara, Y. Nakamura, E. W. Cross, S. Sakaguchi, J. T. White
This study shows that thymic imprinting causes naive CD4 T cells to have different cytokine responses, leading to varied Treg induction and effector function.
bioRxiv · Oct 8, 2023 · PreprintImmunology