Y. Qian

Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

This paper introduces DRAM, a method for transcriptome-wide m5C detection using deaminase and reader proteins, showing high overlap with BS-seq data and supporting low-input RNA.

Camel milk affects serum metabolites by modulating the intestinal microflora

This study shows that camel milk modulates gut microbiota and serum metabolites in rats, with beneficial bacteria and metabolites resembling those of healthy individuals.

Thymically imprinted differential responsivity of naive CD4 T cells to IL2 results in a heterogeneity of both Treg induction and subsequent effector functioning

This study shows that thymic imprinting causes naive CD4 T cells to have different cytokine responses, leading to varied Treg induction and effector function.

Estrogen prevents age-dependent beige adipogenesis failure through NAMPT-controlled ER stress pathway

This study shows estrogen prevents age-related failure in beige adipogenesis by controlling ER stress via NAMPT, improving energy expenditure and glucose tolerance in mice.

Discovering optimal kinetic pathways for self-assembly using automatic differentiation

This paper uses automatic differentiation to optimize kinetic pathways for self-assembly, identifying strategies to avoid kinetic traps and improve assembly yield in multi-subunit complexes.

Temporal control by co-factors prevents kinetic trapping in retroviral Gag lattice assembly

This study uses a reaction-diffusion model to show that co-factors like IP6 delay Gag lattice assembly, preventing kinetic trapping and enabling productive lattice formation.

Cdkn2a regulates beige fat maintenance through BECN1-mediated autophagy

This study shows that Cdkn2a regulates beige fat maintenance via BECN1-mediated autophagy, with implications for obesity and diabetes treatment.

Multiple omic investigations of freeze tolerance adaptation in the aquatic ectothermic vertebrate, the Amur sleeper

The paper investigates freeze tolerance in the Amur sleeper using genomic, transcriptomic, and metabolomic analyses to identify genetic and molecular mechanisms underlying this adaptation.

Growth limitation via chemically complex carbohydrates reduces sensitivity of synthetic human gut communities to perturbations

This study shows that complex carbohydrates reduce microbial community sensitivity to perturbations by limiting growth and altering species interactions in synthetic human gut communities.

An atypical ABC transporter is involved in antifungal resistance and host interactions in the pathogenic fungus Cryptococcus neoformans

This study identifies PDR6, an atypical half-size ABC transporter in Cryptococcus neoformans, showing its role in antifungal resistance and host interactions.

E3 ligase TRIM47 positively regulates endothelial activation and pulmonary inflammation through potentiating the K63-linked ubiquitination

This study shows TRIM47 enhances endothelial activation and pulmonary inflammation by promoting K63-linked ubiquitination of TRAF2, leading to NF-κB and MAPK pathway activation.

ASFV pD345L protein negatively regulates NF-kB signaling through inhibiting IKK kinase activity

This study identifies pD345L as an ASFV protein that inhibits NF-κB signaling by blocking IKK kinase activity, providing insights into ASFV immune evasion mechanisms.

Engineered AIM-based Selective Autophagy to Degrade Proteins and Organelles

The paper introduces a method to degrade specific proteins and organelles using engineered autophagy receptors, demonstrating its effectiveness in plant and transient expression systems.

Direct activation of endothelial cells by SARS-CoV-2 nucleocapsid protein is blocked by Simvastatin

This study identifies SARS-CoV-2 nucleocapsid protein as a potent activator of human endothelial cells, showing that simvastatin inhibits this activation through TLR2/NF-κB and MAPK pathways.

Mechanisms Driving Genome Reduction of a Novel Roseobacter Lineage Showing Vitamin B12 Auxotrophy

The paper identifies a novel Roseobacter lineage, CHUG, with reduced genomes and vitamin B12 auxotrophy, suggesting a free-living lifestyle and genome reduction driven by relaxed purifying selection.

An embryonic zebrafish model to screen disruption of gut-vascular-barriers upon exposure to ambient ultrafine particles

This study uses zebrafish embryos to show that exposure to ultrafine particles disrupts the gut-vascular barrier by modulating Notch signaling.

Temporal Metabolic Characteristics and Transcriptomic Landscape of Islets and Liver Reveal Dynamic Pathophysiology and Interorgan Crosstalk in High-fat Diet-induced Diabetes

This study examines the temporal metabolic and transcriptomic changes in islets and liver of mice on high-fat diet, revealing dynamic pathophysiology and interorgan crosstalk in diabetes.

Molecular evolution of SARS-CoV-2 structural genes: evidence of positive selection in spike glycoprotein

This study identifies positive selection in the SARS-CoV-2 spike gene, particularly the D614G mutation, which may enhance viral entry and adaptability during the pandemic.

The Nucleocapsid Protein of SARS-CoV-2 Abolished Pluripotency in Human Induced Pluripotent Stem Cells

This study shows that SARS-CoV-2 nucleocapsid protein reduces pluripotency in human iPSCs, causing them to lose differentiation ability and adopt fibroblast-like morphology.

APOL1 Variant-Expressing Endothelial Cells Exhibit Autophagic Dysfunction and Mitochondrial Stress

This study shows that APOL1 risk variants in endothelial cells impair mitochondrial function, lysosome integrity, and autophagy, with IFN-gamma exacerbating these effects in heterozygous cells.

Tissue engineered model of hepatic breast cancer micrometastasis shows host-dependent colonization patterns and drug responses

This paper develops a 3D tissue engineered model of hepatic micrometastasis from triple negative breast cancer, showing host-dependent colonization patterns and drug responses.

Understanding the Ca2+-dependent Fluorescence Change in Red Genetically Encoded Ca2+ Indicators

The paper analyzes nine red GECIs to determine the factors causing Ca2+-dependent fluorescence changes, finding three distinct classes based on their mechanisms.

A genetically encoded Ca2+ indicator based on circularly permutated sea anemone red fluorescent protein

The paper develops and validates a new red fluorescent calcium indicator, K-GECO1, based on a circularly permutated RFP from a sea anemone, tested across multiple cell types and organisms.

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

This study identifies 535 novel genetic loci associated with blood pressure traits in over one million individuals of European ancestry.