Depletion of bleomycin hydrolase (Blmh) downregulates histone demethylase Phf8, impairs mTOR signaling/autophagy, accelerates amyloid beta accumulation, and induces neurological deficits in mice
L. Witucki, K. Borowczyk, J. Suszynska-Zajczyk, E. Warzych, P. Pawlak, H. Jakubowski
This study shows that Blmh depletion reduces Phf8, disrupts mTOR/autophagy, increases Aβ, and causes cognitive/neuromotor deficits in mice.
bioRxiv · Mar 20, 2023 · PreprintBiochemistry