Author

L. Witucki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

H. Jakubowski· 3 shared E. Warzych· 1 shared J. Suszynska-Zajczyk· 1 shared K. Borowczyk· 1 shared P. Pawlak· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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3 shared papersBiochemistry

H. Jakubowski

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3 papers

Recent·Most cited

Homocysteine Metabolites Impair the Phf8/H4K20me1/mTOR/Autophagy Pathway by Upregulating the Expression of Histone Demethylase PHF8-targeting microRNAs in Human Vascular Endothelial Cells and Mice

L. Witucki, H. Jakubowski

This study shows that homocysteine metabolites upregulate miR-22-3p and miR-1229-3p, which dysregulate the PHF8/H4K20me1/mTOR/autophagy pathway in vascular endothelial cells and mice.

bioRxiv · Jun 27, 2023Biochemistry

Homocysteine Metabolites Inhibit Autophagy and Elevate Amyloid Beta by Impairing Phf8/H4K20me1-dependent Epigenetic Regulation of mTOR in Cystathionine Beta-Synthase-Deficient Mice

L. Witucki, H. Jakubowski

This study shows that Hcy metabolites impair Phf8/H4K20me1-dependent epigenetic regulation of mTOR, leading to autophagy inhibition and increased Aβ in Cbs-deficient mice.

bioRxiv · Mar 22, 2023 · PreprintBiochemistry

Depletion of bleomycin hydrolase (Blmh) downregulates histone demethylase Phf8, impairs mTOR signaling/autophagy, accelerates amyloid beta accumulation, and induces neurological deficits in mice

L. Witucki, K. Borowczyk, J. Suszynska-Zajczyk, E. Warzych, P. Pawlak, H. Jakubowski

This study shows that Blmh depletion reduces Phf8, disrupts mTOR/autophagy, increases Aβ, and causes cognitive/neuromotor deficits in mice.

bioRxiv · Mar 20, 2023 · PreprintBiochemistry