H. Jakubowski

Homocysteine Metabolites Impair the Phf8/H4K20me1/mTOR/Autophagy Pathway by Upregulating the Expression of Histone Demethylase PHF8-targeting microRNAs in Human Vascular Endothelial Cells and Mice

This study shows that homocysteine metabolites upregulate miR-22-3p and miR-1229-3p, which dysregulate the PHF8/H4K20me1/mTOR/autophagy pathway in vascular endothelial cells and mice.

Homocysteine Metabolites Inhibit Autophagy and Elevate Amyloid Beta by Impairing Phf8/H4K20me1-dependent Epigenetic Regulation of mTOR in Cystathionine Beta-Synthase-Deficient Mice

This study shows that Hcy metabolites impair Phf8/H4K20me1-dependent epigenetic regulation of mTOR, leading to autophagy inhibition and increased Aβ in Cbs-deficient mice.

Depletion of bleomycin hydrolase (Blmh) downregulates histone demethylase Phf8, impairs mTOR signaling/autophagy, accelerates amyloid beta accumulation, and induces neurological deficits in mice

This study shows that Blmh depletion reduces Phf8, disrupts mTOR/autophagy, increases Aβ, and causes cognitive/neuromotor deficits in mice.

Cystathionine β-synthase gene inactivation dysregulates major urinary protein biogenesis and impairs sexual signaling in mice

This study shows that Cbs gene inactivation reduces major urinary protein (Mup) levels and disrupts sexual signaling in mice by affecting Mup biogenesis and behavior.