The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels
A. P. Porter, G. R. M. White, E.-L. Ogg, H. J. Whalley, A. Malliri
This study shows Tiam1 regulates centriole duplication by controlling PLK4 levels through betaTRCP-mediated degradation, leading to proper centriole number and preventing aneuploidy.
bioRxiv · May 20, 2020Cell Biology