A. Malliri

The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRASG12D-driven non-small cell lung cancer

This study compares KRASG12C and KRASG12D mutant NSCLC models, finding that KRASG12D relies more on the PI3K-AKT-mTOR pathway, suggesting tailored combination therapies.

Ultraviolet light-induced collagen degradation inhibits melanoma invasion

This study shows UVR-induced collagen degradation by fibroblasts reduces melanoma invasion and improves survival, but melanoma-associated fibroblasts can restore invasion by increasing collagen synthesis.

The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels

This study shows Tiam1 regulates centriole duplication by controlling PLK4 levels through betaTRCP-mediated degradation, leading to proper centriole number and preventing aneuploidy.

The interaction between the tumour suppressor Dlg1 and the MAGUK protein CASK is required for oriented cell division in mammalian epithelia

This study identifies the CASK-Dlg1 interaction as essential for oriented cell division and epithelial integrity in mammalian cells.