BCR repertoire analysis and cloning of antibody candidates targeting native and Asp7-isomerized β-amyloid
Н. А. Николаев, M.Yu. Myshkin, E.A Kolobova, Irina A. Shagina, O.I. Kechko, K. B. Varshavskaya, Ekaterina V. Barsova, T.V. Grigoreva, V.A. Mitkevich, Ekaterina M. Merzlyak, Sergey A. Kozin, A.A Makarov, Dmitriy M. Chudakov, Sergey Lukyanov, Irina Grigorova, Olga V. Britanova
The paper demonstrates a repertoire-guided workflow to prioritize antibody candidates targeting β-amyloid and its isoAsp7 proteoform, identifying potential heavy-light chain combinations through computational and experimental methods.
bioRxiv · Oct 13, 2026 · PreprintImmunology