Irina Grigorova

BCR repertoire analysis and cloning of antibody candidates targeting native and Asp7-isomerized β-amyloid

The paper demonstrates a repertoire-guided workflow to prioritize antibody candidates targeting β-amyloid and its isoAsp7 proteoform, identifying potential heavy-light chain combinations through computational and experimental methods.

B cell receptor crosslinking can augment T cell help-mediated germinal center B cell selection.

This study shows that T cell help alone can drive GC B cell expansion and plasmablast formation, while BCR crosslinking synergizes with T cell help to enhance these responses when T cell help is limited.

B cells transiently exposed to antigen that return to quiescence respond to protein immunization similarly to naive B cells

The paper shows that B cells previously exposed to antigen and then inactivated respond similarly to immunization as naive B cells.