Rv3400 is a phosphoglucomutase required for trehalose metabolism in Mycobacterium tuberculosis
Yi Liu, Nadine Ruecker, Valwynne Faulkner, Kavitha Rachineni, Nada M. S. Al-Saffar, Elisabeth V Oskoui, Larissa Zarate Garcia, Jessica E. Rowley, Pablo Villacampa Teixeira, Tiago R. D. Costa, Eachan Johnson, Brian D. Robertson, Sabine Ehrt, Gerald J Larrouy-Maumus
This study shows that Rv3400, a β-phosphoglucomutase in M. tuberculosis, is essential for trehalose metabolism, as its deletion increases β-D-glucose 1-phosphate and causes growth defects on trehalose.
bioRxiv · Nov 20, 2025Microbiology