Yi Liu

PROTAC-Mediated Targeting of IKKβ and NR4A1 for AML Therapy

This paper identifies IKKβ and NR4A1 as drivers of AML and develops a PROTAC to degrade them, showing potent cytotoxicity and reduced leukemia progression in mice.

Helminth-remodeled microbial indole-3-lactic acid drives AhR-dependent disease tolerance

This study shows helminth infection remodels gut microbiota to produce ILA, which activates AhR to promote immune tolerance and reduce inflammation in viral infections.

Programmed downregulation of METTL3 is essential for decidualization in both humans and mice

This study shows that reducing METTL3 is necessary for decidualization in humans and mice by maintaining HAND2 expression through m6A modification.

Rv3400 is a phosphoglucomutase required for trehalose metabolism in Mycobacterium tuberculosis

This study shows that Rv3400, a β-phosphoglucomutase in M. tuberculosis, is essential for trehalose metabolism, as its deletion increases β-D-glucose 1-phosphate and causes growth defects on trehalose.

Distinct causes of three phenotypic hallmarks of hematopoietic aging

This study identifies distinct causes for three hematopoietic aging phenotypes using mouse models and single-cell analysis, showing HSC accumulation is NFκB-independent, functional impairment is HSC-autonomous NFκB-driven, and myeloid bias is driven by the NFκB-altered bone marrow environment.

Liver CYP4A autophagic-lysosomal degradation (ALD): A major role for the autophagic receptor SQSTM1/p62 through an uncommon target interaction site

The paper identifies SQSTM1/p62 as a key autophagic receptor for CYP4A degradation, showing its role in preventing proinflammatory metabolite production and insoluble aggregates in liver cells.

H+- and Na+- elicited swift changes of the microtubule system in the biflagellated green alga Chlamydomonas

The paper shows that H+ and Na+ fluctuations rapidly alter microtubules in Chlamydomonas using a fluorescent reporter.