Glucose-lactate metabolic cooperation in cancer: insights from a spatial mathematical model and implications for targeted therapy
Jessica McGillen, Catherine J Kelly, Alicia Martinez-Gonzalez, Natasha K Martin, Eamonn A Gaffney, Philip K Maini, Victor M Perez-Garcia
This paper develops a spatial mathematical model of glucose-lactate metabolism in tumors and finds that metabolic symbiosis is robust and may enhance oxygenation, suggesting potential for targeted therapy.
bioRxiv · Sep 4, 2014Cancer Biology