Cancer BiologybioRxiv
Glucose-lactate metabolic cooperation in cancer: insights from a spatial mathematical model and implications for targeted therapy
Jessica McGillen, Catherine J Kelly, Alicia Martinez-Gonzalez…·Victor M Perez-Garcia
This paper develops a spatial mathematical model of glucose-lactate metabolism in tumors and finds that metabolic symbiosis is robust and may enhance oxygenation, suggesting potential for targeted therapy.
DOI 10.1016/j.jtbi.2014.09.018