Spatiotemporal transcriptomics reveals distinct responses of ALDH1A1-positive and ALDH1A1-negative midbrain dopaminergic neurons to alpha-synuclein overexpression
Carmen-Jeanette Stepek, Eanna B Ryan, Javier Villegas-Salmerón, Felicia New, Kalyan Chavda, David Clifford Henshall, Donato A. Di Monte, Jochen H.M. Prehn, Ayşe Ulusoy, Niamh M. C. Connolly
This study uses spatial transcriptomics to show that ALDH1A1+ and ALDH1A1- midbrain dopaminergic neurons respond differently to alpha-synuclein overexpression, with distinct transcriptional changes over time.
bioRxiv · Jul 21, 2026 · PreprintNeuroscience