Niamh M. C. Connolly

CDKL5 deficiency alters cell subtype-specific molecular programmes and intercellular signalling in the mouse hippocampus

This study uses snRNA-seq to analyze gene expression changes in the hippocampus of CDKL5-deficient mice, identifying cell-type-specific transcriptional alterations and intercellular signaling changes.

Spatiotemporal transcriptomics reveals distinct responses of ALDH1A1-positive and ALDH1A1-negative midbrain dopaminergic neurons to alpha-synuclein overexpression

This study uses spatial transcriptomics to show that ALDH1A1+ and ALDH1A1- midbrain dopaminergic neurons respond differently to alpha-synuclein overexpression, with distinct transcriptional changes over time.

Integrating simulated and experimental data to identify mitochondrial bioenergetic defects in Parkinson's Disease models

The paper develops a computational model of mitochondrial bioenergetics and integrates it with experimental data from Parkinson's Disease models to predict molecular defects and provide a resource for interpreting bioenergetic experiments.

MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control

This study identifies miR-335-5p as a regulator of voltage-gated sodium channels, showing that its modulation can influence seizure activity in epilepsy models.

Potent and lasting seizure suppression by systemic delivery of antagomirs targeting miR-134 timed with blood-brain barrier disruption

This study shows that systemic delivery of Ant-134, timed with BBB disruption after status epilepticus, suppresses seizures in mice with long-lasting effects.

A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy

The paper identifies functional miRNAs and their targets involved in seizure suppression in temporal lobe epilepsy using animal models and functional screens.