Damaged glomeruli in proliferative pediatric lupus nephritis exhibit a C5a-C5aR1 induced fibrotic transcriptional program
Sarah McCuaig, Easton Elliott, Seth Anderson, David Smith, Julia E. Rood, Jael Gaines, Portia A. Kreiger, Edward M. Behrens
The paper identifies a C5a-C5aR1 signaling pathway driving fibrosis in damaged glomeruli of pediatric lupus nephritis using spatial transcriptomics and bulk RNA-seq.
bioRxiv · Mar 15, 2026 · PreprintImmunology