Author

Jael Gaines

Children's Hospital of Philadelphia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

David Smith· 1 shared Easton Elliott· 1 shared Edward M. BehrensiD· 1 shared Julia E. RoodiD· 1 shared Portia A. Kreiger· 1 shared Sarah McCuaigiD· 1 shared Seth AndersoniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

David Smith

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1 paper

Recent·Most cited

Damaged glomeruli in proliferative pediatric lupus nephritis exhibit a C5a-C5aR1 induced fibrotic transcriptional program

Sarah McCuaig, Easton Elliott, Seth Anderson, David Smith, Julia E. Rood, Jael Gaines, Portia A. Kreiger, Edward M. Behrens

The paper identifies a C5a-C5aR1 signaling pathway driving fibrosis in damaged glomeruli of pediatric lupus nephritis using spatial transcriptomics and bulk RNA-seq.

bioRxiv · Mar 15, 2026 · PreprintImmunology