AI-Driven Computational Design of Peptide-Based WWP1 Inhibitors as Promising Therapeutic Agents Against Breast Cancer, Including Triple-Negative Subtype
Enrico Mario Alessandro Fassi, Sara Mathlouthi, Elena Maspero, Edoardo Sisti, Giulia Tamboia, Giuseppe Vita, Fabio Forlani, Simona Polo, Alessandro Gori, Kaliroi Peqini, Sara Pellegrino, Gabriella Roda, Jacopo Sgrignani, Andrea Cavalli, Luisa De Cola, , Giovanni Grazioso
This study uses AI to design a peptide inhibitor of WWP1, showing potent activity against breast cancer, especially TNBC, with promising cytotoxic effects and synergistic potential with PI3K inhibitors.
bioRxiv · Aug 10, 2026 · PreprintCancer Biology