Author

Enrico Mario Alessandro Fassi

University of MilanORCID 0000-0001-6282-4273Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:comparative / phylogenetic analysis· 1 Approach:deep learning· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Andrea CavalliiD· 2 shared Gabriella RodaiD· 2 shared Giovanni GraziosoiD· 2 shared Jacopo SgrignaniiD· 2 shared Alessandro GoriiD· 1 shared Edisa PiraniiD· 1 shared Edoardo Sisti· 1 shared Elena MasperoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCancer Biology

Andrea CavalliORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 10, 2026

AI-Driven Computational Design of Peptide-Based WWP1 Inhibitors as Promising Therapeutic Agents Against Breast Cancer, Including Triple-Negative Subtype

Enrico Mario Alessandro Fassi, Sara Mathlouthi, Elena Maspero…·Giovanni Grazioso

This study uses AI to design a peptide inhibitor of WWP1, showing potent activity against breast cancer, especially TNBC, with promising cytotoxic effects and synergistic potential with PI3K inhibitors.

DOI 10.64898/2026.08.08.742959

humanproteomics

𝕏 PostBluesky

BiochemistryComputational and Structural Biotechnology JournalPeer-reviewedJan 1, 2025

A Potent Nonapeptide Inhibitor for the CXCL12/HMGB1 heterocomplex: A Computational and Experimental Approach

Enrico Mario Alessandro Fassi, Edisa Pirani, Valentina Cecchinato…·Giovanni Grazioso

The paper computationally optimizes a peptide inhibitor of the CXCL12/HMGB1 heterocomplex, resulting in a variant with significantly improved affinity and activity.

4 citations

comparative / phylogenetic analysisdrug response / drug discovery

𝕏 PostBluesky