Identification and proteomic profiling of CD90+ small EVs using a refined immunocapture separation approach targeting stromal-derived EV subpopulations in synovial fluid of arthritis patients
Stefanie Kurth, Edveena Hanser, Simone Haener Massimi, Stavros Giaglis, Florian M. Geier, Dominik Bürri, Katarzyna Buczak, Ute Heider, Stefan M. Wild, André N. Tiaden, Diego Kyburz
This paper develops an immunocapture method to isolate CD90+ stromal-derived EVs from arthritis synovial fluid and performs proteomic profiling to identify disease-relevant EV subpopulations and biomarkers.
bioRxiv · Mar 12, 2025 · PreprintImmunology