Dominik Bürri

Laminin-α2 is required for the maintenance of the myotendinous junction in vivo

This study shows that laminin-α2 is essential for maintaining the myotendinous junction structure, and mechanical unloading affects its integrity in a mouse model of LAMA2-related muscular dystrophy.

Non-cytolytic re-engineering of a viral vaccine vector enables durable effector-memory T cell immunity by reinforcing type I IFN induction

This paper re-engineers a cytolytic viral vector to be non-cytolytic, enhancing CD8 T cell immunity through reinforced type I IFN signaling.

Identification and proteomic profiling of CD90+ small EVs using a refined immunocapture separation approach targeting stromal-derived EV subpopulations in synovial fluid of arthritis patients

This paper develops an immunocapture method to isolate CD90+ stromal-derived EVs from arthritis synovial fluid and performs proteomic profiling to identify disease-relevant EV subpopulations and biomarkers.

Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data

The paper benchmarks eight tools for identifying and quantifying alternative polyadenylation sites from RNA-seq data using real, synthetic, and 3'-end sequencing data.

ZARP: An automated workflow for processing of RNA-seq data

ZARP is an RNA-seq analysis workflow that automates data processing using Snakemake, reducing hands-on time for users by integrating best practices and generating detailed reports.

Shortening of 3' UTRs in most cell types composing tumor tissues implicates alternative polyadenylation in protein metabolism

The paper develops a computational method to analyze 3' UTR length changes in tumor tissues and finds widespread shortening of 3' UTRs in LUAD, suggesting APA plays a role in protein metabolism.