Edward C. Stites

Analysis of RAS as a tumor suppressor

This study challenges the notion of RAS as a tumor suppressor by showing that data supporting this role are consistent with known RAS biology using a mathematical model.

A computational panel of pathological RAS mutants with implications for personalized medicine and genetic medicine

This paper develops a computational model of 16 oncogenic RAS mutants and 14 RASopathy mutants to analyze their signaling strengths and implications for personalized medicine.

Differences in sensitivity to EGFR inhibitors could be explained by described biochemical differences between oncogenic Ras mutants

The paper uses a mathematical model to show that biochemical differences between KRAS mutants explain differential sensitivity to EGFR inhibitors.