Author

Edward C. Stites

Washington University in St. LouisORCID 0000-0002-3783-7336Unclaimed ORCID profile · follow to get notified of new preprints

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Edward C. Stites3 papers

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Andréy S. ShawiD· 1 shared Peter CarlipiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

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2 top collaborators · 0 mutual co-author links

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1 shared paperSystems Biology

Andréy S. ShawORCID

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2 papers

Recent·Most cited

Analysis of the Modulation of RAF Signaling by 14-3-3 Proteins

Peter Carlip, Edward C. Stites

The paper develops a mathematical model of RAF activation modulated by 14-3-3 proteins, showing that weak binding stabilized by avidity explains experimental observations of RAF activation upon 14-3-3 overexpression.

Bulletin of Mathematical Biology · Apr 21, 2026Peer-reviewedSystems Biology

A quantitative systems pharmacology analysis of KRAS G12C covalent inhibitors

Edward C. Stites, Andréy S. Shaw

This paper uses a computational systems pharmacology model to analyze KRAS G12C inhibitors, identifying potential strategies to improve their effectiveness and understanding resistance mechanisms.

CPT Pharmacometrics & Systems Pharmacology · Feb 27, 2018Peer-reviewedSystems Biology