Retention of DLK1 in the endoplasmic reticulum identifies roles for EGF domain-specific O-glycans in the secretory pathway
Yuko Tashima, Yohei Tsukamoto, Natsumi Tsukamoto, Yuji Kondo, Ehsan Uddin, Wakako Furukawa, Shiori Go, Hiromu Arakawa, Hiroyuki Kaji, Hideyuki Takeuchi, Tetsuya Okajima
This study investigates the role of EGF domain-specific O-glycans in the secretory pathway using DLK1 as a model, revealing distinct roles for O-fucose, O-glucose, and O-hexose modifications in ER transport.
FEBS Journal · Jul 10, 2025Peer-reviewedBiochemistry