Tetsuya Okajima

This study investigates the role of EGF domain-specific O-glycans in the secretory pathway using DLK1 as a model, revealing distinct roles for O-fucose, O-glucose, and O-hexose modifications in ER transport.

The paper identifies a specific O-glucose glycan extension on NOTCH1 EGF10 that impacts ligand binding and signaling, revealing new enzymatic pathways and structural features of Notch glycosylation.