Mitochondrial Dysfunction is Part of a Novel Mechanism for Chemotherapy-Induced Neuropathic Pain
Reem Sakas, Saher Abu-Ata, Yara Nakhleh-Francis, Nasser Abd Elkarim, Akhilesh Kotiyal, Henry Politte, Yaseen Awad-Igbaria, Jean F. Soustiel, Eilam Palzur
This study identifies persistent spinal mitochondrial dysfunction and increased mPTP susceptibility as features of chemotherapy-induced neuropathic pain and supports mitochondrial protection as a therapeutic strategy.
bioRxiv · Nov 9, 2026 · PreprintNeuroscience