PERSIST: A programmable RNA regulation platform using CRISPR endoRNases
Breanna DiAndreth, Noreen Wauford, Eileen Hu, Sebastian Palacios, Ron Weiss
The paper introduces PERSIST, a CRISPR-based RNA regulation platform that enables programmable gene circuit design through modular RNA-level switches, showing resistance to silencing compared to transcriptional regulation.
bioRxiv · Dec 15, 2019 · PreprintSynthetic Biology