Cryo-EM structure of a type VI secretion system delivered membrane-depolarizing toxin involved in bacterial antagonism
Jake Colautti, Dmitry Shatskiy, Eileen M. Bates, Nathan P. Bullen, Alexander Belyy, John C. C. Whitney
The paper presents the cryo-EM structure of Ptx2, a VasX family effector, revealing its multi-domain architecture and conformational flexibility, and identifies key features for its toxic activity.
Cell Reports · Sep 1, 2025Peer-reviewedMicrobiology