Author
Michael G. DeGroote Institute for Infectious Disease ResearchORCID 0000-0002-1461-0999Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Yaxi Wang, Jake Colautti, Larry A. Gallagher…·Joseph D. Mougous
The paper identifies an Esx secretion system in Actinomycetota that defends against parasitic Patescibacteria by sensing epibionts and triggering a transcriptional response.
Matthew Van Schepdael, Iman Asakereh, Jake Colautti…·Gerd Prehna
This study investigates the mechanism by which Eag chaperones release effector transmembrane domains using biochemical, biophysical, and structural approaches.
Jake Colautti, S Garrett, John C. C. Whitney
This study identifies a family of antibacterial proteins from Gram-positive bacteria that kill a broad range of bacteria through receptor-independent entry and degradation of essential cellular components.
Jake Colautti, Dmitry Shatskiy, Eileen M. Bates…·John C. C. Whitney
The paper presents the cryo-EM structure of Ptx2, a VasX family effector, revealing its multi-domain architecture and conformational flexibility, and identifies key features for its toxic activity.