Brain neurosteroids are natural anxiolytics targeting α2 subunit γ-aminobutyric acid type-A receptors
EJ Durkin, Laurenz Muessig, Tanja Herlt, Michael J. Lumb, Ryan Patel, Philip Thomas, Damian P. Bright, Rachel Jurd, Stephen J. Moss, Anthony Henry Dickenson, Francesca Cacucci, Trevor G. Smart
This study identifies 2-GABAAR as a key target for neurosteroid anxiolytic effects, showing its importance for anxiety but not depression or analgesia.
bioRxiv · Nov 8, 2018 · PreprintNeuroscience