Stephen J. Moss

This study shows that activating KCC2 improves neurophysiological and behavioral symptoms in female Rett syndrome mice.

This study shows that activating KCC2 during development reduces seizures, cognitive, and behavioral issues in adult CDKL5-deficient mice, but adult treatment is less effective.

This study identifies opposing roles of p38α phosphorylation and arginine methylation in TDP-43 proteinopathy, showing that phosphorylation promotes aggregation while methylation reduces it.

This study shows estradiol increases local synaptic protein synthesis in both sexes, but mTOR signaling is sex-specifically required for certain synaptic proteins.

This study shows that KCC2 is essential for the survival of mature neurons but not for their development or structural formation.

This study isolates and characterizes multi-protein complexes containing Kcc2 from brain plasma membranes, identifying novel interactors and phosphorylation sites that may regulate its function.

The paper identifies KCC2 as a convergence point for ASD/Epi risk genes through proteomic analysis and shows its interaction with FMRP targets and effects on GABAergic inhibition.

This study shows that estradiol restores dendritic spine density in a cellular model of schizophrenia and depression by modulating DISC1 function and synaptic protein distribution.

The paper investigates the effects of USP14 and UCHL5 inhibition on ubiquitinated protein accumulation in mammalian cells, identifying distinct substrates regulated by each deubiquitinase.

This study identifies 2-GABAAR as a key target for neurosteroid anxiolytic effects, showing its importance for anxiety but not depression or analgesia.