Toward Improving Immunotolerance for Stem Cell-Derived Islets
Quan Zhou, Hongfei Li, Dario Gerace, Igor Nikolskly, Xi Wang, Jennifer Hyoje-Ryu Kenty, Jing‐Ping Zhang, Matthew Hinderhofer, Elaine Robinson, Douglas A. Melton
The paper demonstrates that transplanting human stem cell-derived islets into the mouse testis induces immune tolerance through suppressive cytokines and regulatory T cells, improving islet survival.
bioRxiv · Sep 15, 2022 · PreprintDevelopmental Biology