Douglas A. Melton

The paper identifies IAPP as a marker for mature stem cell-derived β cells that maintain stable insulin production in vitro and in vivo, and finds that aconitine enhances IAPP expression.

The paper demonstrates that transplanting human stem cell-derived islets into the mouse testis induces immune tolerance through suppressive cytokines and regulatory T cells, improving islet survival.

This study profiles the epigenome during human islet differentiation, revealing epigenetic priming of lineage-defining loci and the role of LMX1B in endocrine progenitor regulation.

This paper introduces cNMF, a matrix factorization method to disentangle cell-type identity and activity programs from scRNA-Seq data, showing it improves cell type hierarchy and identifies novel activity programs.