Author

Pragya Gupta

AstraZeneca (Sweden)ORCID 0000-0002-1392-9906Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Pragya Gupta1 paper · Institute of Genomics and Integrative Biology

Biology Disciplines

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Bioengineering· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Aathira Sarath ChandraniD· 1 shared Aditya Ramdas Iyer· 1 shared Annarita MiccioiD· 1 shared Anne ChalumeauiD· 1 shared Arvinden VRiD· 1 shared Elena Retana· 1 shared Harie Vignesh· 1 shared Jonathan S. YeniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioengineering

Aathira Sarath ChandranORCID

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2 papers

Recent·Most cited

Enhanced γ-globin reactivation and sickle cell correction through a repressor-to- activator motif switch in the HBG1/2 promoters

Anne Chalumeau, Panagiotis Antoniou, Maria Bou Dames, Pierre Martinucci, Elena Retana, Pragya Gupta, Mike A. Firth, Muralidhar Reddivari, Aathira Sarath Chandran, Jonathan S. Yen, Martin Peterka, Marcello Maresca, Mégane Brusson, Annarita Miccio

This paper demonstrates that replacing the BCL11A repressor binding site with a TAL1:GATA1 activator motif in HBG1/2 promoters enhances γ-globin reactivation and corrects sickle cell disease in hematopoietic stem/progenitor cells.

Molecular Therapy — Nucleic Acids · Jun 6, 2026Peer-reviewedBioengineering

Scalable noninvasive amplicon-based precision sequencing (SNAPseq) for genetic diagnosis and screening of β-thalassemia and sickle cell disease using a next-generation sequencing platform

Pragya Gupta, Arvinden VR, Priya Thakur, Rahul C. Bhoyar, Vinodh Saravanakumar, Narendra Varma Gottumukkala, Sangam Giri Goswami, Mehwish Nafiz, Aditya Ramdas Iyer, Harie Vignesh, Rajat Soni, Nupur Bhargava, Padma Gunda, Suman Lata Jain, Vivek Gupta, , Sivaprakash Ramalingam

This paper introduces SNAPseq, a high-throughput NGS method for detecting β-thalassemia and sickle cell disease with 100% sensitivity and specificity using noninvasive samples.

Frontiers in Molecular Biosciences · Dec 13, 2023Peer-reviewedGenetic & Genomic Medicine