Discovery of tumoricidal DNA oligonucleotides by effect-directed in-vitro evolution
Noam Mamet, Yaniv Amir, Erez Lavi, Liron Bassali, Gil Harari, Itai Rusinek, Nir Skalka, Elinor Debby, Mor Greenberg, Adva Zamir, Anastasia Paz, Neria Reiss, Gil Loewenthal, Irit Mazza Avivi, Avichai Shimoni, , Ido Bachelet
This paper describes an in-vitro evolution platform for discovering DNA oligonucleotides with tumoricidal activity and selectivity, showing efficacy against chemotherapy-resistant tumors.
bioRxiv · Jun 16, 2019 · PreprintSynthetic Biology