Write and Read: Harnessing Synthetic DNA Modifications for Nanopore Sequencing
Uri Bertocchi, Assaf Grunwald, Gal Goldner, Eliran Eitan, Sigal Avraham, Shani Dvir, Jasline Deek, Yael Michaeli, Brian Yao, Jennifer Listgarten, Jared T. Simpson, Winston Timp, Yuval Ebenstein
This paper introduces a 'write-and-read' framework using synthetic DNA modifications to enable nanopore sequencing to detect chemically altered nucleotides and expand the sequence alphabet.
ACS Nano · Nov 3, 2025Peer-reviewedBioengineering