A deep neural network provides an ultraprecise transcriptomic clock of the short-lived fish Nothobranchius furzeri and identifies predictive genes translatable to human aging.
Elisa Ferrari, Kathrin Reichwald, Philipp Koch, Marco Groth, Mario Baumgart, Alessandro Cellerino
The paper develops a deep learning model called SA-DNN to create an ultraprecise transcriptomic aging clock in the short-lived fish N. furzeri and translates it to human aging with 3-year accuracy.
bioRxiv · Nov 26, 2022 · PreprintGenomics