Marco Groth

The chloride cotransporter NKCC1 regulates self-renewal of hippocampal neural stem cells via the transcription factor Sox11

This study shows that NKCC1 regulates hippocampal neural stem cell self-renewal via Sox11, with reduced NKCC1 in aging promoting symmetric division and decreased neurogenesis.

Metabolic modeling reveals the aging-associated decline of host-microbiome metabolic interactions in mice

This study uses multi-omics and metabolic modeling in mice to show that aging reduces host-microbiome metabolic interactions, affecting key host pathways involved in intestinal barrier function and homeostasis.

The Tgf-β family member Gdf6Y determines the male sex in Nothobranchius furzeri by suppressing oogenesis-inducing genes

This study identifies Gdf6Y as the male sex-determining gene in Nothobranchius furzeri by suppressing female-specific genes through TGF-β signaling.

The Aging Synapse: An Integrated Proteomic And Transcriptomic Analysis

This study investigates changes in the synaptic proteome and transcriptome during aging, revealing decoupling between transcripts and proteins and altered ribosomal gene distribution.

The Greenland shark (Somniosus microcephalus) genome provides insights into extremelongevity

The paper presents a chromosome-level genome assembly of the Greenland shark and identifies genomic features associated with its extreme longevity.

Transcriptome analysis of different strains of the turquoise killifish Nothobranchius furzeri identifies signatures associated with heritable lifespan differences

Tau alters global gene expression affecting chromatin in the early stages of Alzheimer's disease

The paper shows that Tau affects global gene expression and chromatin structure in early Alzheimer's disease stages through cellular and transcriptomic analysis.

Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes

The paper identifies RFX7 target genes through multi-omics analysis, revealing their role in tumor suppression and neuronal processes.

A deep neural network provides an ultraprecise transcriptomic clock of the short-lived fish Nothobranchius furzeri and identifies predictive genes translatable to human aging.

The paper develops a deep learning model called SA-DNN to create an ultraprecise transcriptomic aging clock in the short-lived fish N. furzeri and translates it to human aging with 3-year accuracy.

The HPA stress axis shapes aging rates in long-lived, social mole-rats

The paper investigates how the HPA stress axis influences aging in long-lived mole-rats, finding that reproductive status affects stress regulation and lifespan.

The WT1-like transcription factor Klumpfuss maintains lineage commitment in the intestine

The paper identifies Klumpfuss as a transcription factor that restricts enteroblast fate to enterocytes in Drosophila via Notch signaling.

Higher transcriptome stability during aging in long-lived giant mole-rats compared to short-lived rats

This study compares transcriptome stability during aging between long-lived giant mole-rats and short-lived rats, finding greater stability in mole-rats.

Naked mole-rat transcriptome signatures of socially-suppressed sexual maturation and links of reproduction to aging

The paper compares transcriptomes of breeders and non-breeders in naked mole-rats and guinea pigs to show socially suppressed sexual maturation and links between reproduction and aging.

A miRNA catalogue and ncRNA annotation of theshort-living fish Nothobranchius furzeri

The paper presents a comprehensive miRNA and ncRNA catalogue for the short-lived fish Nothobranchius furzeri and compares it to other fish species.

MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging

This study shows miR-29 regulates iron homeostasis in the brain by reducing iron uptake, preventing excessive accumulation and age-related damage.

MicroRNAs provide the first evidence of genetic link between diapause and aging in vertebrates

The paper identifies miRNAs that regulate both diapause and aging in killifish, showing overlapping genetic networks between these processes in vertebrates.