Alessandro Cellerino

The paper compares gene function and expression in dormant cells of yeast spores and killifish diapause embryos, finding conserved transcriptomic and proteomic changes across species.

This study shows that miR-29 regulates memory stability, synaptic gene expression, and DNA methylation in adult mouse hippocampus by modulating Dnmt3a levels.

This study examines cardiac aging in Greenland sharks, finding fibrosis, lipofuscin, and oxidative damage but no physiological decline, suggesting resilience to aging.

This study investigates changes in the synaptic proteome and transcriptome during aging, revealing decoupling between transcripts and proteins and altered ribosomal gene distribution.

This study shows that amyloid-beta precursor protein contributes to non-pathological brain aging and learning decline in killifish and humans.

The paper presents a chromosome-level genome assembly of the Greenland shark and identifies genomic features associated with its extreme longevity.

This study develops epigenetic clocks and lifespan predictors for the killifish Nothobranchius furzeri using DNA methylation data, showing high accuracy in age and lifespan estimation.

The paper shows that Tau affects global gene expression and chromatin structure in early Alzheimer's disease stages through cellular and transcriptomic analysis.

The paper shows that aging in killifish brains reduces basic amino acid-rich proteins through translation pausing, not transcription or proteasome issues, revealing a vulnerability in nucleic-acid protein biogenesis.

The paper develops a deep learning model called SA-DNN to create an ultraprecise transcriptomic aging clock in the short-lived fish N. furzeri and translates it to human aging with 3-year accuracy.

The paper confirms age-dependent noradrenergic neuron degeneration in killifish, with early phospho-Synuclein presence, but not dopaminergic neuron loss.

This paper demonstrates that TDP-43 paralogs in the killifish N. furzeri form amyloid-like aggregates during ageing, suggesting the fish as a model for TDP-43-related neurodegenerative diseases.

This study shows that reduced proteasome activity in aging brains leads to ribosome stoichiometry loss and aggregation, increasing mortality risk in killifish.

The paper uses FUCCI technology to study cell cycle dynamics during diapause entry and exit in annual killifish embryos, revealing coordinated cellular changes during quiescent states.

This study investigates how the hormetic effects of rotenone on lifespan and transcriptome vary with age in a vertebrate species.

The paper identifies ZNF367 as an age-regulated zinc finger factor that modulates embryonic neurogenesis and may contribute to age-related decline in neural stem cell function.

The paper presents a comprehensive miRNA and ncRNA catalogue for the short-lived fish Nothobranchius furzeri and compares it to other fish species.

The paper identifies genes under positive selection in annual African killifishes that are involved in mitonuclear balance, showing convergent evolution in four of five steps related to short lifespan and annual life cycle.

This study shows miR-29 regulates iron homeostasis in the brain by reducing iron uptake, preventing excessive accumulation and age-related damage.

The paper identifies miRNAs that regulate both diapause and aging in killifish, showing overlapping genetic networks between these processes in vertebrates.