NeuroscienceActa Neuropathologica CommunicationsPeer-reviewed
Amyloid precursor protein causes fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load
David Marks, Natalie Heinen, Lisa Bachmann…·Thorsten Müller
The paper shows APP-CT fragments form nuclear aggregates with PML and FE65 in aged human brains, but not in cerebral organoids, and these aggregates are reduced in Alzheimer's disease regions with high plaque load.
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