Thorsten Müller

The paper introduces HIReff, a method for efficiently testing sgRNA performance in CRISPR/Cas9 experiments, showing it is faster, cheaper, and more sensitive than traditional assays.

This study compares methods for knocking-in large DNA fragments using CRISPR, finding that HDR with CRISPR is the most reliable and effective approach.

This paper shows that combining N4-hydroxycytidine and DHODH inhibitors strongly reduces SARS-CoV-2 replication in cell cultures.

The paper shows APP-CT fragments form nuclear aggregates with PML and FE65 in aged human brains, but not in cerebral organoids, and these aggregates are reduced in Alzheimer's disease regions with high plaque load.