Konstanze F. Winklhofer

PINK1 stabilizes RMDN3-VAPB interaction without altering the landscape of mito-ER contact sites

The paper investigates how PINK1 stabilizes the RMDN3-VAPB interaction at mitochondrial-ER contact sites during depolarization without changing the proteomic landscape.

Development and Characterisation of a Versatile Single-Domain Antibody Specific for M1-linked Ubiquitin Chains

This paper develops a single-domain antibody specific for M1-linked ubiquitin chains, enabling their detection and analysis across multiple applications.

Modulation of repopulating microglia in multiple sclerosis models with implication for neuroprotection

The paper investigates microglial dynamics and modulation in MS models using siponimod, showing reduced neuronal damage and changes in microglial markers.

Resting calcium ion fluxes protect cells from fast mitochondrial fragmentation, cell stress responses, and immediate transcriptional reprogramming

The paper shows that resting calcium fluxes prevent mitochondrial fragmentation and transcriptional changes in astrocytes by modulating ER stress and gene expression.

Novel function of Contactin associated protein 1 (Caspr 1)/ Paranodin in embryonic cortical neurons: hypoxia modulated neurite development.

This study investigates how hypoxia affects neurite development in mouse embryonic cortical neurons, revealing a dynamic role for Caspr1 in compensating for hypoxic stress.

Topological confinement by a membrane anchor suppresses phase separation into protein aggregates: implications for prion diseases

This study shows that membrane anchors prevent protein misfolding and aggregation by restricting conformational freedom, with implications for prion diseases.

Antibody-dependent Intracellular neutralisation by TRIM21 is potentiated by HOIP and linear ubiquitin chains

This study identifies HOIP and linear ubiquitin chains as critical for TRIM21-mediated ADIN by recruiting VCP, enhancing virus neutralization.

Brevican, Neurocan, Tenascin-C and Tenascin-R Act as Important Regulators of the Interplay between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons and Otx2

The paper investigates the role of ECM molecules in regulating PNNs, inhibitory interneurons, synaptic distribution, and Otx2 in the visual cortex of knockout mice.

Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease

This paper demonstrates optogenetic delivery of trophic signals using light-activated receptors to suppress disease phenotypes in Parkinson's disease models.

Amyloid precursor protein causes fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load

The paper shows APP-CT fragments form nuclear aggregates with PML and FE65 in aged human brains, but not in cerebral organoids, and these aggregates are reduced in Alzheimer's disease regions with high plaque load.